Epigenetic Reader Domain Degrader

Epigenetic Reader Domain Degraders (30):

Cat. No.	Product Name	Effect	Purity

HY-157592

MMH2-NR	Degrader	98.72%
MMH2-NR a negtive control of MMH2. MMH2 is a CUL4-associated factor (DCAF16)-based bromodomain protein 4 (BRD4) degrader.

HY-117690

dBRD9	Degrader	99.89%
dBRD9,a PROTAC, can selective degrades BRD9. dBRD9 improves the bromine domain binding profile and reduces the binding activity of the whole BET family.

HY-153385

TMX1	Degrader	99.09%
TMX1 is a BRD4 covalent molecular glue degrader. TMX1 selectively recruits DCAF16 to BRD4BD2, resulting in the degradation of BRD4.

HY-101460

Tz-Thalidomide	Degrader	98.01%
Tz-Thalidomide is a tetrazine tagged Thalidomide (HY-14658) (Ligands for E3 Ligase). Tz-Thalidomide has binding affinity for BRD4, with IC₅₀s of 46.25 μM (BRD4-1) and 62.55 μM (BRD4-2). Tz-Thalidomide is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.

HY-139707

Thalidomide-NH-CBP/p300 ligand 2	Degrader	99.85%
Thalidomide-NH-CBP/p300 ligand 2 (P-007) is a PROTAC-based CBP and p300 degrader (extracted from patent WO2020173440).

HY-156568

SMD-3040	Degrader
SMD-3040 is a potent and selective of SMARCA2 PROTAC degrader (DC₅₀: 12 nM). SMD-3040 contains SMARCA2/4 ligand, linker and VHL ligand. SMD-3040 demonstrates excellent degradation selectivity for SMARCA2 protein over SMARCA4 protein.SMD-3040 achieves strong tumor growth inhibition in xenograft models.

HY-107425A

cis-MZ 1	Degrader
cis-MZ 1 is a negative control of MZ 1 (HY-107425). cis-MZ 1 is a PROTAC.html" class="link-product" target="_blank">PROTAC targeting to BRD4.

HY-153459

PROTAC BRD4 Degrader-19	Degrader	98.83%
PROTAC BRD4 Degrader-19 (compound 176) is a PROTAC that targets BRD4 protein for degradation. PROTAC BRD4 Degrader-19 can be used in cancer research.

HY-163410

AU-24118	Degrader
AU-24118 is orally bioavailable proteolysis targeting chimera (PROTAC) degrader of mSWI/SNF ATPases (SMARCA2 and SMARCA4) and PBRM1.

HY-153632

PROTAC BRD9 Degrader-6	Degrader	98.19%
PROTAC BRD9 Degrader-6 is a potent degrader of BRD9 (IC₅₀=0.13 nM), can be used for research of BAF complex-related disorders.

HY-156744

DBr-1	Degrader
DBr-1 is a potent BRD9 degrader.

HY-143328

PROTAC BRD4 Degrader-17	Degrader
PROTAC BRD4 Degrader-17 (compound 13i) is a potent PROTAC BRD4 Degrader, with IC₅₀ values of 29.54 nM (BRD4 (BD1)) and 3.82 nM (BRD4 (BD2)). PROTAC BRD4 Degrader-17 significantly attenuates G2/M progression associated Cyclin B1 expression. PROTAC BRD4 Degrader-17 significantly induces apoptosis in MV-4-11 cells.

HY-162240

SJH1-51B	Degrader
SJH1-51B is a potent PROTAC degrader of BRD4. SJH1-51B has anti-tumor effect.

HY-161368

BRD-SF2	Degrader
BRD-SF2 is a BRD4-targeted PROTAC degrader (DC₅₀: 17.2 μM) (Blue: VHL ligand, black: linker, pink: BRD4 ligand).

HY-163019

EN884	Degrader
EN884 is a BRD4 degrader via a SKP1- and proteasome-dependent manner. EN884 can be used in synthetic proteolysis targeting chimeras (PROTACs).

HY-157491

K2-B4-5e	Degrader
K2-B4-5e is a E3 ligase KLHDC2-based BRD4 and androgen receptor (AR) degradation PROTAC. K2-B4-5e is capable of inducing rapid and robust degradation of BET-family and AR proteins in cells.

HY-160262

AR/BET protein degrader-1	Degrader
AR/BET protein degrader-1 (Compound 149) is an Androgen Receptor and BET (bromodomain and extra-terminal domain) protein degrader that can be used in cancer research.

HY-153820

PROTAC BRD4 Degrader-20	Degrader
PROTAC BRD4 Degrader-20 (compound 195) is an bifunctional compound and an degrader of BRD4.

HY-149948

PROTAC BRD3/BRD4-L degrader-2	Degrader
PROTAC BRD3/BRD4-L degrader-2 is a PROTAC molecule and can selectively degrade cellular BRD3 and BRD4-L with K_i values of 16.91 and 2.8 nM, respectively. PROTAC BRD3/BRD4-L degrader-2 also has robust antitumor activity in mouse xenograft models. PROTAC BRD3/BRD4-L degrader-2 can be used for the research of cancer.

HY-143327

PROTAC BRD4 Degrader-16	Degrader
PROTAC BRD4 Degrader-16 is a potent PROTAC BRD4 Degrader, with IC₅₀ values of 34.58 nM (BRD4 (BD1)) and 40.23 nM (BRD4 (BD2)). PROTAC BRD4 Degrader-16 ignificantly attenuates G2/M progression associated Cyclin B1 expression. PROTAC BRD4 Degrader-16 significantly induces apoptosis in MV-4-11 cells.

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